__Matrix Spectral Decomposition
(matSpDlite) - estimate the equivalent number of independent variables in a
correlation ( r) matrix.__

*matSpDlite takes the same input at matSpD, but ONLY outputs the
analysed LD correlation matrix and Veff and VeffLi estimates (i.e., does not perform time-consuming
varimax/promax rotations) thus allowing users to obtain
Veff/VeffLi values for large numbers (1000s) of variables.
Given the sign of the correlation is not important with regard to multiple test correction, matSpD now automatically analyses the absolute values of your correlation matrix.
Below I provide downloadable R scripts to perform matSpDlite analysis on your local machine. *

Analogous to my SNPSpD
approach, matSpDlite
provides a measure of the equivalent number of independent variables in
a correlation (*r*) matrix, by examining the ratio of observed eigenvalue
variance (after spectral decomposiiton) to its theoretical maximum. Please
refer to the SNPSpD
webpage for further information.

It is worth noting that although the SNPSpD
approach utilises an LD correlation measure which is not technically appropriate
for SNPs, which are multinomial (categorical/ordinal) variables, I've found
the results comparable to using Spearman's rho. Indeed, it is generally
accepted that use of Pearson's correlation (*r*) [appropriate for
interval/numerical data] on categorical/ordinal data, rarely affects substantive
research conclusions. Nonetheless, one may wish to upload their preferred
matrix of correlations using this interface.

The matSpDlite interface takes one file as
input [please use short simple file names (i.e., no spaces or special characters)]:

1) a space or tab delimited ascii (ansi)
text file containing your correlation (*r*) matrix ("corr.matrix") without row and column names.

The following links provide an example
of such an input file and its corresponding output:

corr.matrix
- input file,

results
- output file.

Cheverud JM (2001) A simple correction for multiple comparisons in interval mapping genome scans. Heredity 87:52-8

Li J, Ji L (2005) Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95:221-227

Nyholt DR (2004) A simple correction for multiple testing for SNPs in linkage disequilibrium with each other. Am J Hum Genet 74(4):765-769.

R Development Core Team (2003) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, http://www.R-project.org (accessed March 1, 2004)

Download an R script matSpDlite.R
to perform matSpDlite analysis on your local machine.

Download some newer R scripts
matSpDlite.R
matSpDliteNewAbsMatrix.R
matSpDliteNewMatrix.R
to perform matSpDlite analysis on your local machine.

Page last updated September 18, 2015.

Special thanks to David Smyth (Genepi's
IT guru) for assisting with the development of this web interface.

Tel: +61-7-3362 0258 | Find Us | |

Email: daleN@qimr.edu.au | Contact Us |